Custom Peptides
Cayman Chemical DIhydrocapsaIcIn 10mg
A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 UG/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in normal WI38 lung fibroblasts and H1299, but not A549 or H460, lung cancer cells at 200 µM; a TRPV1 agonist; inhibits TPA-induced NETosis in isolated human neutrophils; induces cortical and systemic hypothermia and reduces infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 0.5 mg/kg
Cayman Chemical RemodelInhydrobromIde 10mg
A 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria; inhibits NAT10
Cayman Chemical L-ArgInIn-d7hydrochlorIde 10mg
An internal standard for the quantification of L-arginine by GC- or LC-MS
Cayman Chemical MalathIon-d10 10mg
An internal standard for the quantification of malathion by GC- or LC-MS
Cayman Chemical mPIPhydrochlorIde 10mg
A reversible, selective, allosteric antagonist of mGluR7 that blocks agonist-induced calcium mobilization (IC50 = 26 nM)
Cayman Chemical Alntus altsma Alnton 10mg
A quassinoid with diverse biological activities; active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively); inhibits radish seed germination by 88% when used at a concentration of 1 mM; inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 cells at 0.1 μM; reduces tumor volume in 22Rv1, LNCaP, and VCaP CRPC mouse xenograft models at 2 mg/kg
Cayman Chemical W-MurIcholIc AcId 10mg
A murine-specific secondary bile acid; formed via enzymatic conversion of β-MCA by a variety of intestinal microorganisms in rat and mouse gut
Cayman Chemical Thromboxn B2 10mg
An inactive metabolite of TXA2; serum levels positively correlate with platelet COX-1 activation; urinary levels reflect intrarenal TXA2 synthesis
Cayman Chemical PSB-1115potasIum salt 10mg
An adenosine A2B receptor antagonist (Ki = 53.4 nM); selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively; selective for A2B over the A3 receptor, which is inhibited only 14% at a concentration of 10 µM; pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical zngbr offIcnle 6Gngerol 10mg
A natural chemical found in fresh ginger that activates TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM)
Cayman Chemical ObtusIfolIn 10mg
An anthraquinone with diverse biological activities; prevents IL-1β-induced increases in NF-κB phosphorylation in chondrocytes at 25-200 µM; reduces cartilage degradation in a mouse model of DMM-induced osteoarthritis at 100 mg/kg; reduces blood glucose levels, as well as serum MDA, NO, triglyceride, and cholesterol levels, and increases serum SOD, GSH, and CAT activity at 30 and 90 mg/kg in a mouse model of STZ-induced diabetes
Cayman Chemical 1PalmItoyl2Oleoylsnglyce 10mg
A phospholipid; a major component of E. coli bilayers; vesicles composed of 1,2,-POPE can be disrupted by polycationic antimicrobials; has been used in combination with other lipids in the formation of LNPs for spleen- and liver-specific targeting in mice
Cayman Chemical Salva plba . B. upafoln 10mg
A flavonoid with diverse biological activities; inhibits iron-dependent lipid peroxidation in a cell-free assay (IC50 = 7.9 µM); inhibits PrP106-126 aggregation in a cell-free assay and reduces PrP106-126-induced cell death in SH-SY5Y cells from 50-150 µM; inhibits the production of hemolysin and leukocidin by MSSA and MRSA and reduces S. aureus-induced hemolysis of erythrocytes in isolated rabbit whole blood at 100 µM; reduces the number of lung CFUs and increases survival in a mouse model of MRSA infection at 100 mg/kg; reduces angiogenesis and tumor volume in a Hep3B mouse xenograft model at 60 mg/kg
Cayman Chemical M8-BhydrochlorIde 10mg
A selective antagonist of TRPM8 that blocks activation by cold, icilin, or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively); decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 knockout mice
Cayman Chemical SLM6031434hydrochlorIde 10mg
An SPHK2 inhibitor (Ki = 0.4 μM for the recombinant mouse enzyme); selective for SPHK2 over SPHK1 (Kis = >20 μM); decreases S1P and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner; reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice at 5 mg/kg; increases blood S1P levels in wild-type mice and rats