Custom Peptides
Cayman Chemical TIgloylLcarnItInchLRIde 10mg
A short-chain acylcarnitine; plasma levels are increased in several melanoma mouse xenograft models compared with non-tumor bearing mice; levels are increased in dried blood spots from neonates with T2 deficiency, an inborn error of isoleucine metabolism characterized by ketoacidosis
Cayman Chemical TrIgonlIn-d3chlorIde 10mg
An internal standard for the quantification of trigonelline by GC- or LC-MS
Cayman Chemical 3-epI UrsolIc AcId 10mg
A pentacyclic triterpenoid; inhibits glycogen phosphorylase and cathepsin L but not cathepsin B (IC50s = 19, 6.5, and >250 µM, respectively); inhibits entry of bovine parainfluenza virus 3 into MDBK cells at 20-50 µM; inhibits the proliferation of MCF-7 cells (IC50 = 18.6 UG/ml)
Cayman Chemical SyrosngopIn 10mg
An inhibitor of MCT1 and MCT4 (IC50s = 2,500 and 40 nM, respectively); inhibits MCT-facilitated lactate export and decreases intracellular pH in HL-60 promyeloblast cells at 10 µM; decreases cell growth in HL-60 cells at 5 µM in combination with metformin; reduces heart norepinephrine levels, MAP, and pulse rate in normotensive dogs at 0.5 mg/kg, i.v.
Cayman Chemical 12-methyl TrIdecnoIc AcId 10mg
A methylated fatty acid; has been found in bovine milk; topical ocular application decreases angiogenesis and corneal opacity in mouse models of alkali- or P. aeruginosa-induced eye injury at 200 µM
Cayman Chemical 25I-NBOHhydrochlorIde 10mg
A derivative of 2C-I that acts as a potent agonist for the human serotonin 5-HT2A receptor (Ki = 0.061 nM); intended for research and forensic applications
Cayman Chemical PSB-1115potasIum salt 10mg
An adenosine A2B receptor antagonist (Ki = 53.4 nM); selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively; selective for A2B over the A3 receptor, which is inhibited only 14% at a concentration of 10 µM; pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical ncalctol 10mg
A vitamin D receptor agonist; induces reporter gene expression in VDR-expressing COS-1 cells at 1 nM; induces differentiation of HL-60 and MG-63 cells (EC50s = 6.2 and 0.18 nM, respectively); reduces the proliferation of MCF-7 cells (EC50 = 4.1 nM); protects primary human keratinocytes against DNA damage induced by UVB irradiation; inhibits acetylcholine- or ATP-induced contractions of aortic rings isolated from spontaneously hypertensive rats at 100 nM; unlike calcitriol, it does not increase serum calcium levels or decrease tibia calcium levels in mice at 80 UG/kg
Cayman Chemical Ro 046790hydroCLOrID hyd 10mg
A 5-HT6 receptor antagonist (Ki = 44.7 nM); selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM; inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75); induces stretching and yawning behavior in rats at 10 and 30 mg/kg; reverses scopolamine-induced decreases in novel object discrimination in rats; attenuates cue-induced cocaine-seeking behavior in rats at 3, 10, and 30 mg/kg
Cayman Chemical 1PalmItoyl3LInolenoylrac 10mg
A diacylglycerol containing palmitic acid and α-linolenic acid at the sn-1 and sn-3 positions, respectively; has been found in the peel and pulp of unripe Dwarf Cavendish bananas
Cayman Chemical AmsacrInhydrochlorIde 10mg
A topoisomerase II poison; stimulates formation of a complex between DNA and topoisomerase II in which the DNA is cleaved and topoisomerase II remains covalently linked to the 5’ end of the DNA cleavage products; inhibits the DNA strand-passing activity of topoisomerase II at a concentration of 20 μg/ml; reduces growth of LoVo human colorrectal carcinoma and T1 human lymphoma cells in a dose-dependent manner; antitumor activity against several murine leukemia, melanoma, lung, colon, and mammary xenograft mouse models
Cayman Chemical MPI-0441138 10mg
A potent inducer of apoptosis and growth inhibitor (EC50 = 2 nM for both processes); has excellent blood brain barrier penetration and is effective in mouse xenograft cancer models